Medicare Negotiated Lower Prices for 15 Drugs:

Medicare Negotiated Lower Prices for 15 Drugs, Including 71% Off Ozempic & Wegovy

Medicare has announced an unprecedented round of prescription drug price negotiations on 15 high-cost medications — including blockbuster diabetes and weight-loss drugs Ozempic, Wegovy, and Rybelsus — with discounts reaching as high as 71%. These reductions represent one of the most significant shifts in U.S. healthcare pricing in decades, offering substantial savings for seniors, taxpayers, and the Medicare program overall.

Key Highlight: If these negotiated prices had been in effect in 2024, Medicare would have saved an estimated $12 billion, while beneficiaries would have saved about $685 million in out-of-pocket costs.

Full List of 15 Drugs with Negotiated Prices

Below is the complete list of negotiated drugs, including therapeutic use and estimated price reductions. These medications were selected because they are among the highest-spend drugs in Medicare Part D, lack generic alternatives, and have been on the market for years.

Drug Name Use 2024 List Price Negotiated 2027 Price Estimated Discount
Ozempic Type 2 diabetes $959/month $274/month 71%
Wegovy Weight loss / Obesity $1,349/month $274–$385/month 71%
Rybelsus Oral semaglutide for diabetes $935/month $274/month 70%
Xtandi Prostate cancer $13,800/month Not yet disclosed 40–60% (est.)
Ibrance Breast cancer $13,000/month Not yet disclosed Up to 50%
Trelegy Ellipta Asthma / COPD $677/month Not yet disclosed 45% (est.)
Pomalyst Multiple myeloma $22,000/month Not yet disclosed 40–50%
Ofev Idiopathic Pulmonary Fibrosis $12,000/month Not yet disclosed 38–45%
Linzess IBS-C / chronic constipation $523/month Not yet disclosed 40%
Entresto Chronic heart failure $676/month Not yet disclosed ~43%
Stelara Crohn’s disease / psoriasis $25,000/dose Not yet disclosed Significant
Symbicort Asthma / COPD $350/month Not yet disclosed 40% range
Soliris Rare autoimmune disorders $678,000/year Not yet disclosed Potentially 60%+
Xarelto Blood thinner $542/month Not yet disclosed ~40%
Huntington’s Disease Drug Rare disease treatment Varies Not yet disclosed 40–50%

Why These Price Cuts Matter

1. Lower Out-of-Pocket Costs for Seniors

Millions of Medicare beneficiaries rely on these drugs for chronic conditions such as diabetes, cancer, lung disease, heart failure, and obesity. The high cost of branded medications often leads seniors to skip doses or forgo treatment. The new negotiated prices are expected to significantly improve affordability and access.

2. Major Savings for Medicare and Taxpayers

The negotiated prices are projected to save Medicare up to $12 billion per year across just these 15 drugs. These savings help strengthen the financial sustainability of Medicare and reduce federal spending.

3. A Historic Shift in U.S. Drug Pricing Policy

Before the Inflation Reduction Act of 2022, Medicare was prohibited from negotiating drug prices. This policy change marks a dramatic shift in federal health policy, granting Medicare the authority to directly negotiate prices with pharmaceutical companies for the first time in decades.

How Much Can a Typical Patient Save?

The table below shows estimated annual savings:

Drug Monthly Savings Annual Savings
Ozempic $685 $8,220
Wegovy $900 $10,800
Xtandi $5,000+ $60,000+
Ibrance $5,000+ $60,000+
Trelegy Ellipta $300 $3,600
Entresto $290 $3,500

Broader Implications for the Pharmaceutical Industry

The pharmaceutical industry has strongly opposed Medicare's new negotiation power, arguing that price reductions could impact research and development. However, Medicare represents the largest single buyer of prescription drugs, and pharma companies may be forced to adapt by altering pricing strategies or focusing on more specialized treatments.

Ripple Effects May Include:

  • Lower launch prices for new drugs
  • Increased investment in rare-disease therapies
  • Pressure on private insurers to demand similar prices
  • Shift toward global harmonization of drug pricing

A New Era of Affordable Medication?

The negotiated prices across these 15 drugs represent a major milestone in controlling U.S. drug costs. Seniors can expect to pay significantly less for life-saving treatments, Medicare will save billions, and the pharmaceutical industry will evolve to a new pricing environment.

This moment may mark the beginning of a long-awaited shift toward transparency, affordability, and fairness in drug pricing across the entire healthcare system.


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